Keywords: Image Reconstruction, Neurofluids, Single-PLD, Multi-PLD
Motivation: Perfusion of the choroid plexus (ChP) is crucial for maintaining brain homeostasis and glymphatic function,which is significantly influenced by age.
Goal(s): Our goal was to perform a comprehensive and quantitative comparison between single-delay and multi-delay ASL measurements of ChP perfusion while investigating influence of age.
Approach: 28 healthy subjects underwent test-retest scans ~1 week apart.CBF/ATT ChP values and grey/white matter were quantified to evaluate the test-retest reliability.
Results: CBF in ChP showed good test-retest repeatability and a significant negative correlation with age.ATT in ChP was greater than 2sec in ~12.85% of voxels,causing around 10% CBF underestimation when ASL signals were acquired with single-PLD.
Impact: Single and multi-delay ASL showed similar test-retest repeatability for measuring ChP perfusion. However, the underestimation of ATT with single-delay ASL affects the accuracy of the results. Multi-delay ASL with model-fitting analysis is recommended for measuring ChP perfusion.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords