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Abstract #0339

Motion corrected MP2RAGE neonatal imaging at ultra-high field with inline reconstruction.

Daniel West1, Zihan Ning1, Ayse Sila Dokumaci1, Yannick Brackenier1, Lucilio Cordero-Grande2, Raphael Tomi-Tricot3, Sarah McElroy3, Philippa Bridgen4,5, Pierluigi Di Cio4,5, Sharon L. Giles1,5, Ines Tomazinho5,6, Cidalia Da Costa5,6, Dario Gallo5,6, Alexandra F. Bonthrone6, Jon Cleary1,5, Tomoki Arichi6, Jo Hajnal1,6, and Shaihan Malik1,6
1Imaging Physics & Engineering Research Department, School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, 2Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid & CIBER-BBN, ISCII, Madrid, Spain, 3MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, 4London Collaborative Ultra high field System (LoCUS), King's College London, London, United Kingdom, 5Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, 6Early Life Imaging Research Department, School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom

Synopsis

Keywords: Motion Correction, Motion Correction, MP2RAGE, Neonatal, Ultra-High Field

Motivation: Traditionally acquired 3D MP2RAGE datasets are liable to motion artefacts due to long scan times. This is exacerbated in neonatal scanning when motion is involuntary and unpredictable.

Goal(s): Combine an optimized MP2RAGE 7T neonatal protocol with DISORDER joint motion estimation and image reconstruction and implement Gadgetron inline reconstruction.

Approach: A neonatal cohort was scanned at 7T using our motion corrected MP2RAGE acquisition. Reconstructions were processed offline or inline before qualitative and quantitative assessment of image quality.

Results: Images after motion correction are sharper and show reduction in image artefacts across all 18 datasets. Quantitative metrics and radiologist scores are improved with statistical significance.

Impact: DISORDER acquisition and reconstruction significantly improves the quality of T1w neonatal imaging at 7T using MP2RAGE, as indicated by both quantitative metrics and radiological scoring. Deployment of Gadgetron-based inline DISORDER reconstruction enables scanner preview of the motion corrected 3D volumes.

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Abstract

Keywords