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Abstract #0364

Motion-robust approach for 4D cardiac MRI using 2D real-time acquisitions and slice-to-volume reconstruction (SVR)

Ye Tian1, Anand Joshi1, Kevin Lee1, Parveen Garg2, Junaid Zaman2, Jon Detterich3, John Wood3, and Krishna S. Nayak1
1Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, 2Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 3Pediatrics and Radiology, Children’s Hospital Los Angeles, Los Angeles, CA, United States

Synopsis

Keywords: Arrhythmia, Cardiovascular, low field, real-time MRI

Motivation: 4D cardiac cine is a powerful tool for comprehensive cardiac function assessment. However, current methods are sensitive to breathing patterns, body motion, and arrhythmia, resulting in 10-20% failure rates.

Goal(s): To develop a 4D cardiac cine approach requiring no patient corporation, that is robust to breathing patterns, irregular motion, and arrhythmia.

Approach: Multi-slice 2D real-time spiral bSSFP with synchronized ECG is acquired in 4 cardiac orientations, followed by slice-to-volume registration, achieving 1mm3 isotropic resolution cardiac cine with 25 cardiac phases.

Results: This method provided 4D cardiac cine in 8:47±1:02minutes for volunteers and arrhythmia patients, with ejection fraction highly correlated to breath-held cine (r=0.99).

Impact: This approach enables 1 mm3 isotropic 4D cardiac cine with zero patient corporation, within an averaged 8:47±1:02 minutes acquisition. This approach may be beneficial in patients that are non-cooperative, children, and those with irregular breathing and/or arrhythmia.

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