Abstract #0368

3D Whole-Ventricle Cardiac Phase-Resolved Dynamic Ferumoxytol-Enhanced Imaging with MR Multitasking

Xi Chen¹, Kim-Lien Nguyen^1,2,3,4, and Anthony G Christodoulou^1,2,4

¹Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ²Physics and Biology in Medicine Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States, ³Division of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA, United States, ⁴Department of Bioengineering, UCLA, Los Angeles, CA, United States

Synopsis

Keywords: Myocardium, Ischemia, Ferumoxytol

Motivation: Steady-state ferumoxytol-enhanced MRI can estimate fractional myocardial blood volume. We aimed to determine the feasibility of first-pass dynamic ferumoxytol-enhanced imaging which has potential to provide complementary myocardial blood flow measurements, especially in patients contraindicated for gadolinium.

Goal(s): To achieve continuous-acquisition 3D whole-ventricle cardiac phase-resolved dynamic ferumoxytol-enhanced MRI.

Approach: The MR multitasking framework was used to reconstruct 3D cardiac phase-resolved, dynamic ferumoxytol-enhanced MRI images from 3 healthy subjects and 1 patient.

Results: Preliminary in vivo results show potential for a comprehensive assessment of myocardial perfusion and for detecting small perfusion defects.

Impact: We proposed a dynamic ferumoxytol-enhanced cardiac MRI technique which has 3D whole-ventricle coverage and is non-ECG gated and free-breathing. It may provide the groundwork for a comprehensive assessment of myocardial blood flow and blood volume in a single acquisition.

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