Keywords: Tractography, Data Analysis, Diffusion MRI, Tractography, Cortical Connectivity
Motivation: Tractography is a powerful tool for studying white matter, but its effectiveness in the developing brain is limited by low anisotropy, gyral bias, and partial volume effects.
Goal(s): We developed an approach for precise reconstruction of white matter pathways in the infant brain, especially in relation to the cortex.
Approach: Our method combines sub-voxel information from diffusion MRI with cortical geometry from anatomical MRI to guide tractography.
Results: Our method produces tractograms connecting to the cortex at both ends, covering 99% of the cortical mesh. This enables infants cortical connectivity quantification while minimizing the influence of gyral bias and low anisotropy.
Impact: Our tractography method outperforms commonly used algorithms in generating accurate tractograms for studying early human brain development.
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