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Abstract #0393

Precision Cortex Tractography for the Developing Brain

Khoi Huynh1,2, Sahar Ahmad1,2, Guoye Lin1,2, and Pew-Thian Yap1,2
1Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Synopsis

Keywords: Tractography, Data Analysis, Diffusion MRI, Tractography, Cortical Connectivity

Motivation: Tractography is a powerful tool for studying white matter, but its effectiveness in the developing brain is limited by low anisotropy, gyral bias, and partial volume effects.

Goal(s): We developed an approach for precise reconstruction of white matter pathways in the infant brain, especially in relation to the cortex.

Approach: Our method combines sub-voxel information from diffusion MRI with cortical geometry from anatomical MRI to guide tractography.

Results: Our method produces tractograms connecting to the cortex at both ends, covering 99% of the cortical mesh. This enables infants cortical connectivity quantification while minimizing the influence of gyral bias and low anisotropy.

Impact: Our tractography method outperforms commonly used algorithms in generating accurate tractograms for studying early human brain development.

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Keywords