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Abstract #0395

A 200-micron structural connectivity atlas of the post-mortem human brain using HPC global tractography on the Chenonceau dataset

Simon Legeay1,2, Felix Matuschke2,3, Bastien Herlin1, Markus Axer2,3,4, Christophe Destrieux5,6, Ivy Uszynski1,2, and Cyril Poupon1,2
1BAOBAB, NeuroSpin, Université Paris-Saclay, CNRS, CEA, Gif-Sur-Yvette, France, Saclay, France, 2AIDAS Joint Institute, CEA, Research Centre Jülich, Saclay, France, Jülich, Germany, 3Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany, 4Department of Physics, University of Wuppertal, Wuppertal, Germany, 5UMR 1253, iBrain, Université de Tours, Inserm, Tours, France, 6CHRU de Tours, Tours, France

Synopsis

Keywords: Tractography, Structural Connectivity, Ex vivo; preclinical MRI; high-resolution

Motivation: Questions about the complete structural connectivity of the human brain remain unresolved. There is a need for high-resolution mapping to unveil finer-scale connections that conventional techniques may miss.

Goal(s): This study aims to combine a high-resolution post-mortem human brain dataset with an advanced global tractography algorithm to achieve unprecedented levels of detail.

Approach: We used ExaTract, a massively parallelized global tractography approach dedicated to supercomputer architecture, and fiber clustering methods to process the Chenonceau dataset at the mesoscale.

Results: This work produced the first mesoscale atlas of human brain connectivity using global tractography, mapping structural connections at resolutions finer than previously achieved.

Impact: This deep phenotyping approach represents a significant advance in the human brain structural connectivity mapping. Including subcortical and intracortical connections at very high level of details, it provides a valuable reference dataset for comparison with conventional MRI tractography in vivo.

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Keywords