Keywords: Vascular/Vessel Wall, Cardiovascular, Heart, Vascular, Structure, Function, Ferumoxytol
Motivation: Practical drawbacks of 4D and 5D MR techniques for imaging of structural heart disease pose significant barriers to the widespread adoption of multi-dimensional approaches in clinical practice.
Goal(s): To implement 4D-MUSIC in a single breath-held acquisition with immediate inline reconstruction, and to assess its feasibility in adult patients.
Approach: A single breath-held 4D cardiac phase-resolved (BH 4D-MUSIC) ferumoxytol-enhanced MRI pulse sequence was implemented and its feasibility in adult patients with structural heart disease was evaluated.
Results: BH 4D-MUSIC was successfully acquired and reconstructed inline in all patients, with breath hold durations range of 17-24 seconds and 8-16 cardiac phases.
Impact: Ferumoxytol-enhanced single breath-held 4D MUSIC is feasible, extending its potential applications beyond children under anesthesia to adults and older children with cardiovascular disease.
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