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Abstract #0402

Four-Dimensional, Ferumoxytol-Enhanced MUSIC in a Single Breath-Hold: Technical Feasibility in Structural Heart Disease

J. Paul Finn1, Shu-Fu Shi1, Kim-Lien Nguyen1, Arash Bedayat1, Takegawa Yoshida1, Ning Jin2, Fei Han3, and Xiaodong Zhong1
1UCLA, Los Angeles, CA, United States, 2SIEMENS, Chicago, IL, United States, 3SIEMENS, Los Angeles, CA, United States

Synopsis

Keywords: Vascular/Vessel Wall, Cardiovascular, Heart, Vascular, Structure, Function, Ferumoxytol

Motivation: Practical drawbacks of 4D and 5D MR techniques for imaging of structural heart disease pose significant barriers to the widespread adoption of multi-dimensional approaches in clinical practice.

Goal(s): To implement 4D-MUSIC in a single breath-held acquisition with immediate inline reconstruction, and to assess its feasibility in adult patients.

Approach: A single breath-held 4D cardiac phase-resolved (BH 4D-MUSIC) ferumoxytol-enhanced MRI pulse sequence was implemented and its feasibility in adult patients with structural heart disease was evaluated.

Results: BH 4D-MUSIC was successfully acquired and reconstructed inline in all patients, with breath hold durations range of 17-24 seconds and 8-16 cardiac phases.

Impact: Ferumoxytol-enhanced single breath-held 4D MUSIC is feasible, extending its potential applications beyond children under anesthesia to adults and older children with cardiovascular disease.

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Keywords