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Abstract #0404

Superiority of Ferumoxytol MRI Over Pre-Contrast Imaging in Patients With Intra-Axial Malignant Brain Lesions

William Strauss1, Csanad Varallyay2, Rochelle Fu3, Laszlo Szidonya3, Lisa Muir3, Amy Huddleston3, Dana Branton4, and Edward Neuwelt3
1Independent Contractor, Marblehead, MA, United States, 2RAYUS Radiology, Portland, MA, United States, 3Oregon Health Science University, Portland, OR, United States, 4Covis Pharmaceuticals, Waltham, MA, United States

Synopsis

Keywords: Contrast Agents, Contrast Agents, Cancer, Novel Contrast Mechanisms

Motivation: Patients with contraindications to gadolinium-based contrast agents (GBCAs), such as those with renal impairment, require alternative imaging options that ensure safety without compromising diagnostic quality.

Goal(s): This study aimed to demonstrate the superiority of ferumoxytol (FER)-enhanced MRI over pre-contrast imaging in assessing malignant brain lesions, focusing on improving lesion visualization.

Approach: This study was conducted by an independent clinical research organization and adhered to FDA guidelines. Three neuroradiologists evaluated FER-enhanced MRI images against pre-contrast scans in 153 patients with primary or metastatic brain tumors.

Results: FER-enhanced MRI demonstrated significant improvement in lesion visualization compared to pre-contrast imaging.

Impact: The results from this study provide strong evidence that ferumoxytol could serve as a safe and effective alternative to gadolinium-based contrast agents, particularly for patients with contraindications, potentially leading to its FDA approval for brain tumor imaging.

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Keywords