Abstract #0408

Comparison of T1 sensitivity to ferumoxytol at 0.55T versus 3T: a preclinical cardiac MRI study

Shahriar Zeynali^1,2, Hazar Benan Unal^1,2, Eric Anttila³, David Gross³, Rohan Dharmakumar², and Behzad Sharif^1,2

¹Laboratory for Translational Imaging for Microcirculation, Weldon School of Biomedical Engineering, Purdue University, Indianapolis, IN, United States, ²Department of Radiology & Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ³MED Institute, West Lafayette, IN, United States

Synopsis

Keywords: Myocardium, Low-Field MRI

Motivation: Ferumoxytol-enhanced cardiac MRI has potential to detect ischemia by enabling more accurate and sensitive assessment of changes in myocardial blood volume. However, in-vivo comparison of ferumoxytol behavior at different field strengths is lacking.

Goal(s): To compare the myocardial and blood T1 sensitivity to ferumoxytol and T1 map quality between 0.55T and 3T.

Approach: We analyzed and compared a) relative myocardial and blood T1 changes with different ferumoxytol doses, b) artifact severity at two field strengths

Results: 0.55T demonstrated 2.5-fold greater myocardial T1 sensitivity to ferumoxytol compared to 3T, with significantly reduced susceptibility artifacts.

Impact: The increased ferumoxytol sensitivity at 0.55T enables potential dose reduction while maintaining diagnostic quality, offering a more robust platform for MBV assessment. This could particularly benefit stress/rest T1 reactivity measurements where detecting subtle MBV changes is crucial.

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