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Abstract #0410

Flip Angle Optimization for Hepatobiliary Phase MRI at 0.55 T in Patients with Neuroendocrine Tumors

Cheng William Hong1, Yang Yang1, Isabelle Remick1, Pan Su2, Pedro Itriago-Leon2, Waqas Majeed2, Emily Bergsland3, Thomas A Hope1, and Michael A Ohliger1
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Siemens Medical Solutions USA Inc., Malvern, PA, United States, 3Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Liver, Low-Field MRI, flip angle, gadoxetate, mid-field

Motivation: The optimal flip angle for hepatobiliary phase imaging at 0.55T is not known.

Goal(s): To determine the flip angle that maximizes liver enhancement and lesion contrast for hepatobiliary phase imaging at 0.55T.

Approach: Fourteen patients with metastatic neuroendocrine tumors were imaged at 0.55T using a T1 VIBE research sequence systematically across a range of flip angles between 10 and 70 degrees. Normalized liver lesion contrast, liver vessel contrast, and liver signal intensity were computed.

Results: Normalized liver-lesion and liver-vessel contrast is maximized at a flip angle of 30 degrees, while normalized liver signal intensity is maximized at 20 degrees.

Impact: In patients with metastatic neuroendocrine tumors imaged at 0.55T, a flip angle of 30 degrees maximizes lesion contrast on the hepatobiliary phase. Improving hepatobiliary phase quality at 0.55T may improve MRI accessibility for patients with known or suspected liver lesions.

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