Abstract #0414

MR-derived Hepatic Fat Fraction and Stiffness in Chronic Liver Disease Patients: Comparing Different Vendors and Field Strengths

Nader S Metwalli¹, Ahmed M Ghanem¹, Jazmin Rivera², Jatin R Matta¹, Khaled Z Abd-Elmoniem¹, Ahmed Hamimi³, Ahmed M Gharib¹, and Ronald Ouwerkerk¹

¹National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/National Institutes of Health (NIH), Bethesda, MD, United States, ²Department of Molecular Biology, Princeton University, Princeton, NJ, United States, ³Department of Radiology, The University of Chicago, Chicago, IL, United States

Synopsis

Keywords: Liver, biomarkers

Motivation: Liver MRE stiffness and PDFF measurements need consistency across MRI scanners, but previous studies showed mixed results for PDFF across vendors and field strengths.

Goal(s): To compare these measurements across two different vendor scanners and field strengths (1.5T vs 3T) in chronic liver disease (CLD) patients.

Approach: 30 CLD patients underwent same-day MRE and PDFF measurements within 2 hours using both scanners, with PDFF sequences calibrated using a phantom.

Results: MRE differences were small, 0.24 kPa, p=0.03, within clinically acceptable range (concordance correlation coefficient, CC>0.9), whereas PDFF differences were large at 5 %, p<0.001, with CC<0.9, and beyond the clinically acceptable range.

Impact: MRE measurement differences between both scanners were significant but small within clinically acceptable range (concordance correlation, CC>0.9). However, for PDFF and MRS on 1.5T and 3T PDFF and 1.5T PDFF, the differences were significantly large and not clinically acceptable (CC<0.9).

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.