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Abstract #0417

31P-MRS saturation transfer to assess hepatic ATP synthesis at 3T in individuals with type-1-diabetes and control volunteers

Marc Jonuscheit1,2, Benedict Korzekwa1,2, Michael Schär3, Julian Mevenkamp4, Stefan Wierichs1,2, Pavel Bobrov2,5, Sabine Kahl1,2,6, Michael Roden1,2,6, and Vera B Schrauwen-Hinderling1,2,4
1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany, 2German Center for Diabetes Research (DZD e.V.), München-Neuherberg, Germany, 3Division of Magnetic Resonance Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 5Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany, 6Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

Synopsis

Keywords: Spectroscopy, Spectroscopy, Non-proton, ATP synthesis

Motivation: 31P-MRS saturation transfer for detection of adenosine triphosphate (ATP) synthesis is currently almost exclusively performed at ultrahigh field.

Goal(s): Establishing a method to robustly assess ATP synthesis in human liver using a clinical MRI system.

Approach: A 2D-ISIS sequence was used to assess the hepatic apparent spin-lattice relaxation time of inorganic phosphate (T'1,Pi), equilibrium forward rate constant (kf) and forward ATP exchange flux (FATP) in healthy volunteers (n=9) and participants with type-1-diabetes (T1D) (n=8).

Results: Reproducibility measurements resulted in CVs of 7.1% and 21.3% for T'1,Pi and kf, respectively. Mean hepatic kf and FATP were lower (p=.001 and p=.002) in T1D vs. controls.

Impact: To make the 31P-MRS ST technique more broadly available for metabolic research, the method is established on a clinical scanner, allowing investigation of ATP synthesis in the liver with good localization and is sensitive to changes occurring with T1D.

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