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Abstract #0427

First 7T 19F MRI with labeled cells in a pig model of myocardial infarction using the twin-rf-array system with pTX support for human MR-scanner.

Maxim Terekhov1, Ibrahim Elabyad1, Hamid Marwan1, Farzad Jabbarigargari1, Rebekka Grampp2, Anja Stadtmueller2, Mohamadreza Keshtkar1, Gabrile Ulm3, Sofia Dembski3, Ulrich Hofmann2, Wolfgang Bauer2, and Laura Maria Schreiber1
1Cardiovascular Imaging, Chair of Molecular and Cellular Imaging, University Hospital Würzburg, Comprehensive Heart Failure Center, Wuerzburg, Germany, Germany, 2Cardiology, University Hospital Würzburg, Department of Internal Medicine I, Wuerzburg, Germany, Germany, 3Fraunhofer Translational Center Regenerative Therapies, Wuerzburg, Germany

Synopsis

Keywords: Inflammation, Infiltration, Inflammation, 7T, 19F, labelled cells, rf-array

Motivation: Using ultra-high field may essentially increase the sensitivity of MRI with 19F-labeled immune cells in the pig model.

Goal(s): The dedicated 19F and 1H RF-arrays with pTX-support optimized for pig thorax are necessary for cardiac MRI measurements at ultra-high-field.

Approach: We designed and tested in-vivo twin 16-element arrays for 1H and 19F nuclei with a focus on optimal SNR and g-factor in the region of the heart. pTX-support allows transferring of subject-specific-B1-shimming from 1H to 19F.

Results: The new 7T twin-arrays enables good efficiency of 19F labeled cells detection in the heart and other organs and high quality of 1H MRI for overlay.

Impact: First in-vivo images with 19F-labeled cells in a pig heart were acquired in whole body 7T-scanner using dedicated twin-arrays for 1H and 19F-MRI. pTX support allows subject-specific B1-shimming for both 1H and 19F-imaging and high-quality anatomic cardiac images.

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Keywords