Abstract #0432

Image quality assessment of multi-shot echo-planar diffusion weighted imaging for in vivo breast cancer screening

Kalina V. Jordanova¹, Philip K. Lee¹, Judith Zimmermann¹, Preya Shah¹, Patricia Lan², Arnaud Guidon³, Katherine A. Young¹, Catherine J. Moran¹, Xuetong Zhou^1,4, Bruce L. Daniel^1,4, and Brian A. Hargreaves^1,4,5

¹Radiology, Stanford University, Stanford, CA, United States, ²GE Healthcare, Menlo Park, CA, United States, ³GE Healthcare, Boston, MA, United States, ⁴Bioengineering, Stanford University, Stanford, CA, United States, ⁵Electrical Engineering, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Breast, Breast, Artifacts, Diffusion Reconstruction, Motion Correction, Screening

Motivation: High b-value multi-shot echo-planar imaging (MS-EPI) diffusion weighted imaging (DWI) offers reduced distortion, high resolution, and high contrast that is promising for breast cancer screening. Improvements to reconstruction robustness are enabling use of higher b-values and higher shot counts.

Goal(s): To assess breast MS-EPI DWI image quality versus number of shots and b-value across many exams.

Approach: Two-shot (clinical) and six-shot (research) MS-EPI DWI sequences with different b-values will be used to screen approximately 200 women at high risk for breast cancer. Three raters will evaluate image artifact severity. Average ratings will be calculated for each sequence/b-value.

Impact: Multi-shot DWI EPI can offer efficient, non-contrast enhanced breast cancer screening, but may suffer from artifacts that make images unusable. Evaluating the robustness of multi-shot DWI EPI will direct future efforts to translate these sequences for widespread clinical use.

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