Abstract #0439
Age-related Changes in Brain Metabolites in Early Infancy: A Cross-Sectional Analysis of the First HBCD Data Release
Saipavitra Murali-Manohar1,2, Helge J. Zöllner1,2, Christopher W. Davies-Jenkins1,2, Aaron T. Gudmundson1,2,3, Steve C. N. Hui4,5,6, Yulu Song1,2, Gizeaddis L. Simegn1,2, Zahra Shams1,2, Borjan Gagoski7,8, M. Dylan Tisdall9, Muhammad G. Saleh9,10, Ralph Noeske11, William T. Clarke12, Georg Oeltzschner1,2, Jessica L. Wisnowski13,14, and Richard A. E. Edden1,2
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3The Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore, MD, United States, 4Developing Brain Institute, Children’s National Hospital, Washington D. C., DC, United States, 5Departments of Radiology, The George Washington University School of Medicine and Health Sciences, Washington D. C., DC, United States, 6Departments of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington D. C., DC, United States, 7Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Boston, MA, United States, 8Department of Radiology, Harvard Medical School, Boston, MA, United States, 9Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 10Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, 11GE HealthCare, Munich, Germany, 12Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, 13Department of Radiology and Pediatrics, Children’s Hospital Los Angeles, Los Angeles, CA, United States, 14University of Southern California, Los Angeles, CA, United States
Synopsis
Keywords: Normal Development, Pediatric, Spectroscopy, Brain Metabolites, HBCD
Motivation: Neurometabolite concentration changes in the first few months after birth have not been studied in a large cohort.
Goal(s): To assess early neurochemical development in a large cohort of 0–8 month-old infants by analyzing all available data in the first MRS data release of the HEALthy Brain and Child Development study (“HBCD”).
Approach: Linear combination modeling will quantify 14 neurometabolites in this cross-sectional population. Statistical analyses will test for significant relationships between metabolite levels, birth-age and gestational age.
Impact: Identifying changes in neurochemical levels in the first few months after birth in a large cohort for the first time will help deepen our understanding of the various roles these chemicals play in neurodevelopment.
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