Abstract #0445

Regional Neuromelanin Reduction in the Substantia Nigra in Different Subtypes of Parkinson’s Disease

Hongwei Li¹, Xiali Shao², Jian Wang^2,3, Jia Jia^4,5, Jiankun Dai⁶, Xueying Zhao⁶, Yuchen Liu⁶, Zhensen Chen^1,7, He Wang^1,7, and Lirong Jin⁴

¹Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China, ²Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China, ³Department of Radiology, Zhongshan Hospital, Fudan University (Xiamen Branch), Shanghai, China, ⁴Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China, ⁵Department of Neurology, Shanghai Xuhui Central Hospital, Shanghai, China, ⁶MR Research, GE Healthcare, Beijing, China, ⁷MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, China

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease, Neuromelanin, substantia nigra

Motivation: The intricate pathophysiological mechanisms differentiating these PD subtypes remain unclear.

Goal(s): This study aimed to investigate NM-MRI characteristics in the SNc subregions of PD patients across different clinical subtypes.

Approach: Four groups were included: PD-MMP, PD-IM, PD-DM and HCs. CNR were calculated for the sensorimotor, associative, and limbic territories of the SNc and compared between groups using NM-MRI. The correlation analyses were performed to evaluate the relationships between CNR and clinical scores.

Results: Neuromelanin values showed a gradual decline, with a descending gradient in PD-MMP, followed by PD-IM and PD-DM and regional neuromelanin loss was associated with motor and cognitive impairments.

Impact: These findings suggest underlying pathological mechanisms for PD subtypes and indicate that regional neuromelanin loss is associated with motor and cognitive impairments.

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