Keywords: Parkinson's Disease, Degenerative, Neuroimaging Epicenters
Motivation: Parkinson's disease (PD) is highly heterogeneous and lacks a clear definition of its neuropathological mechanisms, complicating the identification of its origins and progression.
Goal(s): This study aimed to identify neuroimaging epicenters in PD and evaluate their clinical significance.
Approach: We employed a network-theory approach, known as epicenter mapping, on cross-sectional multimodal MRI to identify the most likely sources of structural pathology in PD.
Results: Our results indicate that multiple nuclei in the midbrain, basal ganglia, and various cortical areas of the cerebellum may serve as neuroimaging epicenters in PD, with these features closely associated with patients' clinical symptoms.
Impact: We developed a reliable method for identifying the epicenter using multimodal MRI, offering new insights for exploring the disease's potential sites and their clinical relevance in PD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords