Abstract #0455

The water exchange across the blood-CSF barrier in human choroid plexus detected by relaxation-exchange MRI (REXI)

Xuetao Wu^1,2, Shuyuan Tan³, Yifan Zhang³, Bingjie Jiao³, Fan Jiang³, Yihua Han³, Yi-Cheng Hsu⁴, Rong Xue^1,2, and Ruiliang Bai⁵

¹State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ²University of Chinese Academy of Sciences, Beijing, China, ³Key Laboratory of Biomedical Engineering of Education Ministry, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ⁴MR Collaboration, Siemens Healthcare, Shanghai, China, ⁵Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, China

Synopsis

Keywords: Neurofluids, Neurofluids, Choroid plexus, Blood cerebrospinal fluid barrier, Contrast-agent-free, Relaxation exchange

Motivation: The lack of non-invasive imaging methods for assessing choroid plexus function has limited our understanding of the blood-cerebrospinal fluid barrier (BCSFB).

Goal(s): Our objective was to measure the trans-barrier water exchange rate (k_BCSFB) in human choroid plexus (CP) using MRI.

Approach: We adapted our new imaging method, i.e., relaxation-exchange magnetic resonance imaging (REXI) for the human brain, conducted methodological validation, and measured age-related changes in k_BCSFB.

Results: REXI showed good repeatability in measuring the k_BCSFB in the CP (Intraclass correlation coefficient = 0.88) and detected a 56% decrease in k_BCSFB from the young group (~ 23 years) to the mild-aged group (~ 55 years).

Impact: Considering the growing importance of neurofluids and CP, REXI provides with a new and contrast-agent-free technique to measure the water exchange across BCSFB and serves as a promising neuroimaging tool for evaluating CP function in future clinical studies.

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