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Abstract #0463

Comparison of Water Exchange Rate in Young and Elderly Adults with Diffusion Prepared and Multi-Echo Arterial Spin Labeling MRI

Yufei David Zhu1, Anjan Bhattarai1,2, Barah Albuhwailah1, Xingfeng Shao3, Jan Petr4,5, Klaus Eickel6,7, Matthias Günther6,8, Danny JJ Wang3,9, and Audrey Peiwen Fan1,2
1Biomedical Engineering, University of California, Davis, Davis, CA, United States, 2Neurology, University of California, Davis, Davis, CA, United States, 3Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, 4Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, 5Department of Radiology and Nuclear Medicine, Amsterdam UMC Locatie VUmc, Amsterdam, Netherlands, 6Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany, 7Bremerhaven University of Applied Sciences, Bremerhaven, Germany, 8University of Bremen, Bremen, Germany, 9Radiology & Neurology, University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: Neurofluids, Arterial spin labelling, blood-brain barrier

Motivation: Blood-brain barrier (BBB) water exchange rate (Kw) has emerged as a candidate biomarker for neuropsychiatric and neurodegenerative disorders.

Goal(s): Currently, two arterial spin labeling (ASL) methods—diffusion-prepared (DP) and multi-echo (ME) ASL—exist to assess regional Kw in humans.

Approach: Our study applies the two sequences in a young and elderly cohort to characterize regional Kw in two groups to understand the effect of brain aging on BBB function.

Results: DP and ME ASL exhibit opposing directions of Kw in the same participants with ME ASL showing more focal Kw changes in the temporal lobe and surrounding regions across the two age groups.

Impact: Our study provides novel biological information about water exchange rate (Kw) in different brain regions to understand aging-related changes in blood-brain barrier physiology and advances the understanding of how Kw imaging measures differ between arterial spin labeling methods.

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Abstract

Keywords