Abstract #0470

The feasibility of mean apparent propagator (MAP)-MRI for Assessing the Glymphatic function

Qingping He^1,2, Zhaoqing Li³, Jiayi Liu⁴, Yihua Han⁵, Evren Özarslan*^6,7, and Ruiliang Bai*^1,2

¹School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China, ²Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, China, ³Department of Physical Medicine and Rehabilitation of the Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China, ⁴School of physics, Peking University, Beijing, China, ⁵ZIINT, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ⁶Department of Biomedical Engineering, Linköping University, Linköping, Sweden, ⁷Center for Medical Image Science and Visualization (CMIV) , Linköping University, Linköping, Sweden

Synopsis

Keywords: Neurofluids, Neurofluids, Glymphatic system, MAP-MRI

Motivation: Glymphatic system involves dynamic regulation of cell morphology and interstitial fluid dynamics in brain parenchyma, but there still lacks MRI methods assessing such processes.

Goal(s): To explore the feasibility of mean apparent propagator (MAP)-MRI to measure glymphatic function in brain parenchyma.

Approach: We altered the glymphatic function using different anesthesia protocols (ketamine/xylazine (K/X) and isoflurane (ISO)) and measured MAP-MRI in rat brain in vivo.

Results: MAP-MRI effectively captured differences in the extracellular space in various brain regions (e.g. PAG) of rats under K/X and isoflurane anesthesia. The observed changes were as predicted: K/X anesthesia promoted water displacement more effectively than isoflurane.

Impact: Given the significant role of the glymphatic system in maintaining brain homeostasis, our findings suggest MAP-MRI’s sensitivity to glymphatic function, which makes it a potentially viable method for monitoring glymphatic activity.

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