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Abstract #0504

Distance-Dependent Functional Dysconnectivity and Neurotransmitter Correlates in Major Depressive Disorder

Rui Qian1, Huaijin Gao1, Bowen Qiu1, Baorong Gu1, Zichao Li1, Dan Wu1,2, and Zhiyong Zhao2
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Hangzhou, China, 2Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China

Synopsis

Keywords: Functional Connectivity, Psychiatric Disorders, MDD, FCS, Neurotransmitters

Motivation: The differences between first-episode drug-naïve (FEDN) and recurrent major depressive disorder (RMDD) patients in the functional dysconnectivity and their association with neurotransmitter systems remain poorly understood.

Goal(s): To investigate distance-specific alterations of functional connectivity (FC) and the relationship between functional dysconnectivity and neurotransmitter systems in MDD subtypes.

Approach: We examined distance-dependent FC differences in a large cohort of 848 MDD patients and 794 controls, and integrated them with neurotransmitter density from a public PET dataset.

Results: FEDN and RMDD showed distinct patterns of distance-dependent FC disruption, particularly in long-range connections, with specific correlations with serotonergic, GABAergic, and opioid systems.

Impact: Functional dysconnectivity in MDD subtypes shows distinct distance-dependent patterns and specific correlations with neurotransmitter systems. These findings advance our understanding of subtype-specific pathophysiology and may guide the development of more precise therapeutic strategies for MDD.

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