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Abstract #0507

Severe Brain Network Hierarchy Disorganization in Treatment-Naïve Deficit vs. Non-Deficit Schizophrenia and Neurotransmitter Associations

Chengmin Yang1, Li Yao1, Huilou Liang2, and Su Lui1
1Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, 2GE HealthCare MR Research, Beijing, China

Synopsis

Keywords: Psychiatric Disorders, Psychiatric Disorders, deficit schizophrenia, non-deficit schizophrenia, heterogeneity, functional gradient, neurotransmitter

Motivation: Schizophrenia subtypes (deficit schizophrenia, DS vs. non-deficit schizophrenia, NDS) exhibit different neurodevelopmental trajectories and treatment responses, with limited antipsychotic efficacy for negative symptoms.

Goal(s): To examine whether DS and NDS patients show distinct brain functional hierarchy abnormalities and how they relate to receptor and transporter distributions.

Approach: Resting-state fMRI and high-resolution imaging were used to assess functional gradients, clinical correlations, and neurotransmitter spatial associations in 159 participants.

Results: DS patients showed greater cortical hierarchy compression and stronger serotonergic associations, while NDS exhibited dopaminergic links. These findings highlight distinct neurochemical pathways influencing symptoms.

Impact: This study found that DS showed more severe cortical hierarchy compression linked to serotonergic dysfunction, while NDS was primarily associated with dopaminergic abnormalities, highlighting distinct neurochemical pathways in each subtype.

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Keywords