Abstract #0514

Phase Reversed Interleaved Multi-Echo (PRIME) with phase, field map and motion navigators for highly accelerated distortion-free diffusion MRI

Yohan Jun^1,2, Qiang Liu^3,4, Ting Gong^1,2, Jaejin Cho⁵, Shohei Fujita^1,2, Xingwang Yong^1,2,6, Susie Y Huang^1,2,7, Lipeng Ning^3,8, Anastasia Yendiki^1,2, Yogesh Rathi^2,8,9, and Berkin Bilgic^1,2,7

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, ⁴Department of Electrical and Computer Engineering, Northeastern University, Boston, MA, United States, ⁵Department of Artificial Intelligence and Robotics, Sejong University, Seoul, Korea, Republic of, ⁶Zhejiang University, Hangzhou, China, ⁷Harvard/MIT Health Sciences and Technology, Cambridge, MA, United States, ⁸Department of Psychiatry, Brigham and Women’s Hospital, Boston, MA, United States, ⁹Department of Radiology, Brigham and Women’s Hospital, Boston, MA, United States

Synopsis

Keywords: Diffusion Acquisition, Diffusion Acquisition

Motivation: Current multi-shot diffusion MRI (dMRI) with gSlider RF encoding acquisition has a limited in-plane acceleration factor per shot and substantially long dead time.

Goal(s): To develop a highly accelerated distortion-free dMRI sequence with high fidelity.

Approach: We propose a highly accelerated distortion-free dMRI sequence, PRIME, which benefits from incorporating additional echoes for field map estimation, phase correction, and motion estimation without prolonging TR, especially when gSlider RF encoding is used.

Results: PRIME enables high-fidelity distortion-free dMRI up to 490μm isotropic resolution with the benefit of adding additional echoes utilizing dead time in gSlider RF-encoded acquisitions.

Impact: We propose a highly accelerated distortion-free dMRI sequence, which can achieve 490μm isotropic resolution with high-fidelity field maps, shot-to-shot phase, and motion correction from additional echoes without prolonging repetition time when gSlider RF encoding is used.

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