Keywords: Data Processing, Lung, ultra short echo time
Motivation: UTE MR signal intensity (SI) distributions within the lung are not standardized across patients or over time.
Goal(s): To develop a pulmonary UTE SI normalization method using anatomical references and implement the normalization method in idiopathic pulmonary fibrosis patients.
Approach: SI within the lung is normalized to the median trachea and aorta SI as reference standards for pure air and blood; signal bias fields are generated using spline fit to tissue signals outside of the lung.
Results: Corrected lung measures were consistent over time and were increased in more severe disease.
Impact: This method may be used to develop quantitative parenchymal density measures on UTE MRI as a biomarker to assess cross-sectional differences in disease populations, disease progression and treatment response without the ionizing radiation inherent to gold-standard computed tomography.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords