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Abstract #0521

Pulmonary UTE Signal Intensity Normalization using Anatomical References

Marrissa J McIntosh1, Sarah E Gerard2, Jonathan Altman3, Elizabeth Ramirez4, Riley B Meyer2, Saman Khodaei2, Conner J Wharff1, Rodrigo M Bello1, Abhilash S Kizhakke Puliyakote1, Andrew D Hahn1, and Sean B Fain1,2
1Department of Radiology, University of Iowa, Iowa City, IA, United States, 2Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, IA, United States, 3Carver College of Medicine, University of Iowa, Iowa City, IA, United States, 4University of Illinois Chicago, Chicago, IL, United States

Synopsis

Keywords: Data Processing, Lung, ultra short echo time

Motivation: UTE MR signal intensity (SI) distributions within the lung are not standardized across patients or over time.

Goal(s): To develop a pulmonary UTE SI normalization method using anatomical references and implement the normalization method in idiopathic pulmonary fibrosis patients.

Approach: SI within the lung is normalized to the median trachea and aorta SI as reference standards for pure air and blood; signal bias fields are generated using spline fit to tissue signals outside of the lung.

Results: Corrected lung measures were consistent over time and were increased in more severe disease.

Impact: This method may be used to develop quantitative parenchymal density measures on UTE MRI as a biomarker to assess cross-sectional differences in disease populations, disease progression and treatment response without the ionizing radiation inherent to gold-standard computed tomography.

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