Keywords: Large Animals, Nonhuman Primates, Normal development, ultra-high resolution, diffusion MRI
Motivation: Despite paramount neuroscientific significance of macaque brain model, comprehensive delineation of both long- and short-range tracs of developing macaque brain is not available.
Goal(s): To reveal long- and short-range white matter (WM) tract maturation with cutting-edge tractography using first-of-their-kinds ultra-high-resolution diffusion MRI (dMRI) datasets of developing macaque brains.
Approach: We acquired ultra-high resolution dMRI of neonate, early childhood, and adult macaque brains and traced deep and superficial white matter tracts through advanced dMRI-based tractography.
Results: Comprehensive long- and short-range WM tracts were delineated, characterized by differential microstructural changes across all tracts.
Impact: The revealed maturational processes of the developmental macaque brain WM tracts, specifically the short-range WM tracts, offer unprecedented insights into common and unique features of brain development across primate species.
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