Meeting Banner
Abstract #0528

Maturation of long- and short-range tracts in macaque brain with ultra-high-resolution diffusion MRI

Runjia Lin1,2, Tianjia Zhu1,3, Ziqin Zhang1,3, Minhui Ouyang1,4, and Hao Huang1,4
1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2School of Software, Dalian University of Technology, Dalian, China, 3Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 4Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Large Animals, Nonhuman Primates, Normal development, ultra-high resolution, diffusion MRI

Motivation: Despite paramount neuroscientific significance of macaque brain model, comprehensive delineation of both long- and short-range tracs of developing macaque brain is not available.

Goal(s): To reveal long- and short-range white matter (WM) tract maturation with cutting-edge tractography using first-of-their-kinds ultra-high-resolution diffusion MRI (dMRI) datasets of developing macaque brains.

Approach: We acquired ultra-high resolution dMRI of neonate, early childhood, and adult macaque brains and traced deep and superficial white matter tracts through advanced dMRI-based tractography.

Results: Comprehensive long- and short-range WM tracts were delineated, characterized by differential microstructural changes across all tracts.

Impact: The revealed maturational processes of the developmental macaque brain WM tracts, specifically the short-range WM tracts, offer unprecedented insights into common and unique features of brain development across primate species.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords