Keywords: Biology, Models, Methods, Deuterium
Motivation: Abnormal glucose metabolism is a key feature of Alzheimer's disease (AD).
Goal(s): To employ Deuterium MR Spectroscopy (DMS) for the non-invasive characterisation of glucose metabolism in the early disease phase of the AD mouse model APP/PS1.
Approach: 6 months old APP/PS1 mice were intravenously infused with deuterated glucose and DMS of the brain was applied during 90 minutes, showing signals for HOD, glucose, lactate and glutamine/glutamate.
Results: Their average tissue concentration were higher in APP/PS1 than in wild-type mice indicating increased glucose uptake and glycolytic and TCA-cycle activity, reflecting a hypermetabolic cerebral state in early diseased APP/PS1 mice.
Impact: Employing the non-invasive potential of Deuterium MR Spectroscopy for the simultaneous assessment of glucose uptake, glycolytic and TCA-cycle activity, we demonstrate a hypermetabolic cerebral state in an early stage Alzheimer’s mouse model, which may resemble mild cognitive impairment in humans.
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