Abstract #0550

MR Elastography for early prediction of neoadjuvant chemotherapy efficacy in breast cancer

Anne-Sophie van Schelt¹, Luciana Melina Luque², Aaditya P Sinha^3,4, Belul Shifa⁴, Omar Darwish^1,5, Patriek Jurrius^3,4, Cheryl Gillet⁶, Maddy Parsons⁷, Arnie Purushotham^3,4, and Ralph Sinkus^1,8

¹School of Biomedical Engineering and Imaging Sciences, Kings College London, London, United Kingdom, ²CRUK Scotland Institute, Glasgow, Scotland, ³School of Cancer and Pharmaceutical Sciences, Kings College London, London, United Kingdom, ⁴Breast Unit, Guy’s and St Thomas NHS Foundation Trust, London, United Kingdom, ⁵MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany, ⁶Comprehensive Cancer Centre, Kings College London, London, United Kingdom, ⁷Randall Centre for Cell and Molecular Biophysics, Kings College London, London, United Kingdom, ⁸LVTS, University Paris Diderot, Paris, France

Synopsis

Keywords: Breast, Breast, Elastography

Motivation: Currently, there is no reliable method to predict neoadjuvant chemotherapy (NACT) efficacy during treatment of breast cancer.

Goal(s): This study evaluates MR Elastography (MRE) as a method for early prediction of response in breast cancer patients undergoing NACT by assessing tissue biomechanics.

Approach: MRE was performed in 56 patients pre-NACT and post first cycle (1.1). By analyzing phase-angle (Y) and elasticity dynamics (ratio=pre-NACT /1.1).

Results: We observed that partial-responders exhibit increased stiffness and decreased phase-angle, potentially caused by fibroblast-driven collagen deposition. MRE showed an improved ROC curve (AUC=0.913) using the Y-ratio (RC=5% cut-off) compared to clinical DCE-MRI at post-NACT (AUC=0.690).

Impact: MRE has a strong predictive potential and offers a non-invasive method for early assessment of neoadjuvant chemotherapy efficacy in breast cancer using dynamic changes of the phase-angle determined at pre-treatment and after the first cycle of chemotherapy.

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