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Abstract #0553

Biomechanical parameters for predicting response to neoadjuvant chemotherapy and disease-free survival in breast cancer

Xiaoxia Wang1, Ting Yin2, and Jiuquan Zhang1
1chongqing university cancer hospital, chongqing, China, 2Siemens Healthineers Ltd, chengdu, China

Synopsis

Keywords: Breast, Breast

Motivation: Little is known regarding biomechanical properties temporal changes during neoadjuvant chemotherapy and associated with treatment response in breast cancer.

Goal(s): We investigate temporal changes in neoadjuvant chemotherapy-associated biomechanical parameters quantified by multifrequency MR elastography and assess biomechanical parameters as a predictor of pathologic complete response (pCR) and disease-free survival (DFS).

Approach: We enrolled participants who underwent multifrequency MR-elastography (30,40,50 and 60 Hz) at four timepoints. Tomoelastography postprocessing provided biomechanical maps of shear-wave-speed (c) and loss-angle (φ) as proxies of stiffness and viscosity.

Results: Multifrequency MR elastography–derived biomechanical parameters were valuable biomarkers for pCR and DFS in patients with breast cancer.

Impact: Combining biomechanical parameters quantified by multifrequency MR elastography and clinicopathologic variables showed good performance for predicting pathologic complete response and disease-free survival in breast cancer treated with neoadjuvant chemotherapy.

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