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Abstract #0559

Patellar Cartilage Evolution is Linked to Intra-Limb Baseline Hip Femoral Cartilage: Longitudinal Compositional Multi-Joint Study

Rupsa Bhattacharjee1, Rafeek Thahakoya1, Yurui Qian1, Misung Han1, Fei Jiang2, Richard B Souza1,3, Valentina Pedoia1, and Sharmila Majumdar1
1Department of Radiology & Biomedical Imaging, University of California, San Francisco (UCSF), San Francisco, CA, United States, 22Department of Epidemiology and Biostatistics, University of California, San Francisco (UCSF), San Francisco, CA, United States, 3Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco (UCSF), San Francisco, CA, United States

Synopsis

Keywords: Osteoarthritis, Cartilage, Osteoarthritis, Hip, Knee

Motivation: From gait-retraining perspective, it is crucial to identify the early effects of hip OA, specifically hip cartilage degradation, on the evolution of knee cartilage.

Goal(s): To evaluate whether longitudinal changes in contralateral knee patellar cartilage proteoglycan composition are associated with baseline hip femoral cartilage compositional behavior.

Approach: Comparisons between baseline and follow-up knee patellar T1p study participants were performed. Correlation between relative change in knee patellar cartilage across visits) and baseline T1p of intra-limb hip femoral subregional cartilages were performed.

Results: Relative changes in knee patellar T1p were negatively associated with baseline T1p of intra-limb hip femoral load-bearing posterior-superior cartilage subregion.

Impact: Relationship between longitudinal changes in patellar T1p and baseline T1p of intra-limb hip-femoral load-bearing cartilage, might be useful for the prevention of polyarticular OA development and lead to a better understanding of the propagation of OA from hip to knee.

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Keywords