Keywords: Muscle, CEST & MT, pH, fitting, skeletal muscle, neuromuscular diseases
Motivation: Intramuscular pH is a promising biomarker for neuromuscular disease research which can be assessed with ¹H and ³¹P MRS, though these techniques have limitations, such as reduced spatial resolution.
Goal(s): Chemical Exchange Saturation Transfer (CEST) enables high-resolution pH mapping by measuring exchange rates between metabolites and free water.
Approach: In this study, we used a 3-pool Bloch-McConnell model to fit and extract the exchange rate between creatine and free water.
Results: Sensitivity was assessed in vitro within the physiological pH range and in vivo in leg muscles of healthy volunteers, at rest and post-exercise, and in a patient’s leg.
Impact: This work advances high-resolution pH mapping for neuromuscular disease assessment, offering non-invasive insights into muscle homeostasis. By enhancing sensitivity and spatial resolution in pH measurement, it could improve the monitoring of muscle disorders, benefiting clinical research.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords