Abstract #0567

Neurometabolic Signatures of Cognitive Resilience in Alzheimer's Disease: A Hybrid 3D-MRSI/PET Study

Wenli Li¹, Miao Zhang², Yibo Zhao³, Yudu Li^3,4,5, Wen Jin^3,6, Yaoyu Zhang¹, Jialin Hu¹, Zhi-Pei Liang^3,6, and Yao Li^1,7

¹National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²Department of Nuclear Medicine, Ruijin Hospital, Shanghai, China, ³Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, IL, United States, ⁴Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, IL, United States, ⁵National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Champaign, IL, United States, ⁶Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Champaign, IL, United States, ⁷Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai, China

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease

Motivation: To explore neurometabolic features underlying cognitive resilience (CR) in Alzheimer’s disease (AD).

Goal(s): To identify the neurometabolic signatures of CR that mitigate AD-related glucose hypometabolism on cognition using combined 3D ¹H-MRSI and PET imaging.

Approach: We conducted high-resolution, whole-brain ¹H-MRSI and ¹⁸F-FDG PET imaging with cognitive assessments in 245 participants (114 AD, 50 MCI and 81 controls). Interactions between neurometabolic changes and glucose hypometabolism across cognitive domains were analyzed.

Results: Higher N-acetyl aspartate and lower myo-inositol levels in the temporal lobe mitigated the effects of hypometabolism on global cognitive function. Distinct neurometabolic changes support resilience across different cognitive domains.

Impact: Higher NAA/Cr and lower mI/Cr levels in the parietal and temporal lobes may serve as promising markers of CR in AD. These neurometabolic signatures may provide insights into intervention strategies aimed at slowing cognitive decline in AD.

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