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Abstract #0572

Characterization of cerebrovascular reactivity in aging, Alzheimer’s disease, and vascular dementia using multi-echo, multi-contrast MRI

Elizabeth G. Keeling1,2, Maurizio Bergamino1, Lauren R. Ott1, Molly M. McElvogue1, Anna M. Burke3, Marwan N. Sabbagh3, Nadine Bakkar3, and Ashley M. Stokes1
1Barrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States, 2School of Life Sciences, Arizona State University, Tempe, AZ, United States, 3Barrow Neurological Institute, Phoenix, AZ, United States

Synopsis

Keywords: Alzheimer's Disease, Vascular, Cerebrovascular Reactivity, Multi-Echo, Spin-Echo, Gradient-Echo, Brain, Biomarker, Vascular Dementia

Motivation: Cerebrovascular reactivity (CVR) shows promise as an imaging biomarker of changes in vascular integrity. Microvascular-weighted images may be more specific to disease-related pathology, but these acquisitions suffer from lower contrast-to-noise ratio.

Goal(s): We aim to evaluate CVR in Alzheimer’s disease (AD) and vascular dementia (VaD) using a combined spin- and gradient-echo (SAGE) acquisition.

Approach: SAGE-fMRI, demographic, and cognitive testing data were collected. Total and microvascular-weighted SAGE-fMRI CVR maps were generated. Regional group differences were assessed.

Results: Microvascular-weighted CVR revealed multi-regional deficits for VaD compared to healthy aging and AD. Positive correlations of CVR with cognitive testing and negative correlations with age were observed.

Impact: Complementary assessments of CVR on total and microvascular scales may comprehensively inform on differences in vascular integrity between populations. The microvascular-weighted analysis was sensitive to changes in CVR between groups and may be specific to dementia-related pathology in the microvasculature.

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Keywords