Keywords: Alzheimer's Disease, Vascular, Cerebrovascular Reactivity, Multi-Echo, Spin-Echo, Gradient-Echo, Brain, Biomarker, Vascular Dementia
Motivation: Cerebrovascular reactivity (CVR) shows promise as an imaging biomarker of changes in vascular integrity. Microvascular-weighted images may be more specific to disease-related pathology, but these acquisitions suffer from lower contrast-to-noise ratio.
Goal(s): We aim to evaluate CVR in Alzheimer’s disease (AD) and vascular dementia (VaD) using a combined spin- and gradient-echo (SAGE) acquisition.
Approach: SAGE-fMRI, demographic, and cognitive testing data were collected. Total and microvascular-weighted SAGE-fMRI CVR maps were generated. Regional group differences were assessed.
Results: Microvascular-weighted CVR revealed multi-regional deficits for VaD compared to healthy aging and AD. Positive correlations of CVR with cognitive testing and negative correlations with age were observed.
Impact: Complementary assessments of CVR on total and microvascular scales may comprehensively inform on differences in vascular integrity between populations. The microvascular-weighted analysis was sensitive to changes in CVR between groups and may be specific to dementia-related pathology in the microvasculature.
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