Abstract #0574

Perfusion Velocity in Temporal Lobe Decreases Prior to Its Change in Other Brain Regions in Alzheimer’s Disease

Yihao Guo¹, Tao Liu², Yi Li³, Gloria C. Chiang^3,4, Weiyuan Huang¹, Mony J. de Leon³, Yi Wang⁵, Feng Chen¹, and Liangdong Zhou³

¹Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China, ²Department of Neurology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China, ³Department of Radiology, Brain Health Imaging Institute (BHII), Weill Cornell Medicine, New York, NY, United States, ⁴Department of Radiology, Division of Neuroradiology, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY, United States, ⁵Department of Radiology, MRI Research Institute (MRIRI), Weill Cornell Medicine, New York, NY, United States

Synopsis

Keywords: Alzheimer's Disease, Arterial spin labelling

Motivation: Reduced cerebral perfusion has been demonstrated in patients with Alzheimer’s Disease(AD), but the longitudinal change in cerebral perfusion alteration during disease progression is not well investigated.

Goal(s): We investigated regional perfusion velocity change during AD progression, providing a comprehensive view of the temporal alteration of blood supply and perfusion pattern.

Approach: Quantitative transport mapping(QTM) is applied to quantify blood perfusion velocity from multi-delay ASL data. Granger causality analysis(GCA) was applied to identify the driving regions of QTM velocity change.

Results: We found that the temporal lobe was the driving region and could predict the subsequent QTM velocity changes in other brain regions.

Impact: These findings suggest that the perfusion velocity in temporal lobe supplied by MCA has the earliest change among the whole brain regions, which may be an early biomarker for AD diagnosis and offer a therapeutical target.

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