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Abstract #0578

Pathological Insights into Dementia with Lewy Bodies: The Role of Quantitative Susceptibility Mapping

Greta Venturi1, Elettra Capogna2, Lorenzo Motta1, Lucia Guidi1, Davide Braghittoni1, Luisa Sambati1, Micaela Mitolo1,3, Elena Cantoni 1, Giovanni Sighinolfi1, Raffaele Lodi1,2, and Caterina Tonon1,2
1IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy, 2Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy, 3Department of Biomedical and Neuromotor Sciences, University of Parma, Parma, Italy

Synopsis

Keywords: Dementia, Quantitative Susceptibility mapping, Dementia with Lewy Bodies (DLB); Iron Deposition; Brain MorphologyNeuropsychological Evaluation; Neurodegeneration; Biomarkers; Magnetic Susceptibility;

Motivation: Dementia with Lewy bodies (DLB) presents unique challenges due to overlapping symptoms. Investigating brain iron deposition with quantitative susceptibility mapping (QSM) may provide insights into DLB’s pathogenic mechanisms.

Goal(s): This study aims to investigate structural and magnetic susceptibility (c) changes in the brains of DLB patients, correlating with cognitive performance.

Approach: A cohort of DLB patients underwent advanced MRI techniques, including QSM, to evaluate iron deposition patterns and structural integrity compared to healthy controls.

Results: The study found increased c in various brain regions of DLB patients, correlating with cognitive deficits, highlighting QSM's potential as a biomarker for DLB diagnosis and monitoring.

Impact: This study demonstrates the potential of quantitative QSM as a biomarker for DLB monitoring disease progression. By linking brain iron deposition to cognitive deficits, it paves the way for further research into the underlying mechanisms of DLB.

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