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Abstract #0581

Assessing Neurometabolic Alterations, Glutathione Depletion and Iron Deposition in the Mesostriatal Pathway of Parkinson's Disease

Su Yan1, Bingfang Duan1, Xiaoxiao Zhang2, Ning Zheng2, and Wenzhen Zhu1
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2Clinical & Technical Solutions, Philips Healthcare, Beijing, China

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease, Magnetic resonance spectroscopy; gamma-aminobutyric acid; glutathione; quantitative susceptibility mapping

Motivation: Emerging insights into the pathophysiology of Parkinson's disease (PD) underscore the involvement of dysregulated neurotransmission, iron accumulation and oxidative stress.

Goal(s): Our aim is to explore the interactions among the excitatory and inhibitory neurometabolites, the antioxidant glutathione (GSH), and magnetic susceptibility in PD.

Approach: Spectra-editing of γ-aminobutyric acid (GABA), GSH and quantitative susceptibility mapping were simultaneously employed to reveal disease-specific alterations in the mesostriatal pathway in PD.

Results: PD demonstrated metabolic dysregulation in the nigro-striatal circuits, characterized by a concomitant reduction in GABA and GSH levels, accompanied with iron deposition.

Impact: These findings offer valuable insights into the pathophysiology of PD and may inform future therapeutic strategies targeting metabolic and oxidative stress pathways.

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