Keywords: Parkinson's Disease, Parkinson's Disease, Magnetic resonance spectroscopy; gamma-aminobutyric acid; glutathione; quantitative susceptibility mapping
Motivation: Emerging insights into the pathophysiology of Parkinson's disease (PD) underscore the involvement of dysregulated neurotransmission, iron accumulation and oxidative stress.
Goal(s): Our aim is to explore the interactions among the excitatory and inhibitory neurometabolites, the antioxidant glutathione (GSH), and magnetic susceptibility in PD.
Approach: Spectra-editing of γ-aminobutyric acid (GABA), GSH and quantitative susceptibility mapping were simultaneously employed to reveal disease-specific alterations in the mesostriatal pathway in PD.
Results: PD demonstrated metabolic dysregulation in the nigro-striatal circuits, characterized by a concomitant reduction in GABA and GSH levels, accompanied with iron deposition.
Impact: These findings offer valuable insights into the pathophysiology of PD and may inform future therapeutic strategies targeting metabolic and oxidative stress pathways.
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