Abstract #0584

Macromolecular Proton Fraction Mapping of Subcortical Nuclei in Patients with Parkinson's Disease

Yasuhiro Fujiwara¹, Nobutaka Sakae², Yoshinori Hirakawa³, Hiroyuki Kumazoe³, Kouta Miyamoto³, Hirohito Kan⁴, and Mika Kitajima⁵

¹Department of Medical Imaging Technology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, ²Department of Neurology, National Hospital Organization Omuta National Hospital, Fukuoka, Japan, ³Department of Radiology, National Hospital Organization Omuta National Hospital, Fukuoka, Japan, ⁴Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan, ⁵Department of Diagnostic Imaging Technology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease

Motivation: Imaging biomarkers are needed to detect neurodegeneration in the prodromal stage and predict disease progression in Parkinson's disease.

Goal(s): To assess the utility of macromolecular proton fraction (MPF) mapping and quantitative susceptibility mapping (QSM) of subcortical nuclei for diagnosing Parkinson's disease.

Approach: We performed MPF mapping and QSM in patients with Parkinson's disease and healthy controls.

Results: In multiple subcortical nuclei, patients with Parkinson's disease showed significantly decreased MPF values and significantly increased magnetic susceptibility values compared with that in healthy controls.

Impact: Decreased MPF may reflect neurodegeneration, while increased magnetic susceptibility suggests iron accumulation. Combining MPF and QSM measurements in subcortical nuclei could aid in diagnosing Parkinson's disease.

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