Abstract #0588

Time-Dependent Diffusion MRI Reveals Smaller Cell Size with Stable Volume in Hippocampus and Amygdala during Chemotherapy

Xiaoyu Zhou¹, Diwei Shi², Yao Huang¹, Ting Yin³, Dan Wu⁴, Hua Guo⁵, Junzhong Xu^6,7,8,9, Daihong Liu¹, and Jiuquan Zhang¹

¹Department of Radiology, Chongqing University Cancer Hospital, School of Medicine, Chongqing University, Chongqing, China, ²Center for Nano and Micro Mechanics, Department of Engineering Mechanics, Tsinghua University, Beijing, China, ³MR Research Collaborations, Siemens Healthineers Ltd., Chengdu, China, ⁴Department of Biomedical Engineering, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University College of Biomedical Engineering and Instrument Science, Hangzhou, China, ⁵Center for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua University, Beijing, China, ⁶Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ⁷Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ⁸Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ⁹Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, United States

Synopsis

Keywords: Other Neurodegeneration, Diffusion Modeling

Motivation: Chemotherapy can cause cognitive impairment in breast cancer patients. However, the microstructural changes in hippocampus and amygdala during chemotherapy remain unknown.

Goal(s): To explore the patterns of microstructural changes of hippocampus and amygdala during chemotherapy.

Approach: Volume on T1-weighted imaging and microstructure estimated by JOINT model in hippocampus and amygdala of 37 female breast cancer patients were recorded at baseline (T0), after the first (T1), and sixth (T6) or eighth (T8) cycle of neoadjuvant chemotherapy.

Results: Bilateral hippocampus and amygdala have smaller cell size without volume change in breast cancer patients receiving neoadjuvant chemotherapy.

Impact: By combining Time-Dependent Diffusion MRI and 3D T1WI MRI, a decrease in cell sizes with unchanged volume of hippocampus and amygdala among breast cancer patients was identified with repeated measurements during neoadjuvant chemotherapy, aiding early diagnosis and treatment of chemo-brain.

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