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Abstract #0591

Whole-Brain, High-Resolution Diffusion-Weighted MRSI with Improved Phase Correction

Zepeng Wang1,2 and Fan Lam1,2
1Department of Bioengineering, University of Illinois, Urbana-Champaign, Urbana, IL, United States, 2Beckman Institute for Advanced Science and Technology, Urbana, IL, United States

Synopsis

Keywords: Spectroscopy, Brain, Diffusion-weighted MRSI, microstructrual imaging

Motivation: In vivo DW-MRSI, although a potentially powerful microstructural imaging tool, can suffer from poor resolutions, long acquisition times and motion-induced phase errors.

Goal(s): Whole-brain, high-resolution, DW-MRSI within clinically relevant time.

Approach: A fast multi-slab acquisition with 3D phase navigators and flow-compensated diffusion gradients was developed. Processing strategies integrated spatially varying phase correction and subspace-based reconstruction and quantification.

Results: Phantom and in vivo experiments with validation against a single-voxel technique demonstrated strong qualitative and quantitative performances, e.g., whole-brain metabolite ADC mapping at a 5.2×5.2×5.0 mm3 resolution in around 20mins.

Impact: The proposed method advanced capability of in vivo DW-MRSI and may facilitate compartment/cell-type-specific tissue microstructural investigations.

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Keywords