Keywords: Spectroscopy, Brain, Diffusion-weighted MRSI, microstructrual imaging
Motivation: In vivo DW-MRSI, although a potentially powerful microstructural imaging tool, can suffer from poor resolutions, long acquisition times and motion-induced phase errors.
Goal(s): Whole-brain, high-resolution, DW-MRSI within clinically relevant time.
Approach: A fast multi-slab acquisition with 3D phase navigators and flow-compensated diffusion gradients was developed. Processing strategies integrated spatially varying phase correction and subspace-based reconstruction and quantification.
Results: Phantom and in vivo experiments with validation against a single-voxel technique demonstrated strong qualitative and quantitative performances, e.g., whole-brain metabolite ADC mapping at a 5.2×5.2×5.0 mm3 resolution in around 20mins.
Impact: The proposed method advanced capability of in vivo DW-MRSI and may facilitate compartment/cell-type-specific tissue microstructural investigations.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords