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Abstract #0594

Non-gaussian diffusion of the major intracellular metabolites is sensitive to cerebellar microstructural alterations in essential tremor.

Guglielmo Genovese1, Kadir Șimșek2,3, Marco Palombo2,3, Stephane Lehéricy4,5, Cecile Gallea4,5, and Francesca Branzoli5
1Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway, 2Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology,, Cardiff University, Cardiff, United Kingdom, 3School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom, 4Paris Brain Institute - ICM, Team "Movement Investigations and Therapeutics", Paris, France, 5Paris Brain Institute - ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne University, Paris, France

Synopsis

Keywords: Spectroscopy, Diffusion Acquisition, essential tremor, non-gaussian diffusion, kurtosis representation, cell-specificity, dendritic atrophy, inflammation

Motivation: Essential tremor (ET) is a progressive and debilitating neurological disorder with limited understanding of its pathophysiology. Post-mortem studies indicate cerebellar microstructural changes in neuronal and glial cells.

Goal(s): To provide in-vivo insights into ET-related microstructural changes in neuronal and glial cells.

Approach: Diffusion-weighted MRS measured non-Gaussian diffusivities of intracellular metabolites in ET patients and healthy volunteers. Volumes of interest were placed in the cerebellum and the posterior cingulate cortex as a control region.

Results: Altered non-Gaussian diffusivities of intracellular metabolites in ET cerebellum suggest neuronal and glial microstructural changes. No changes were observed in the control region.

Impact: -Feasibility of in-vivo investigation of microstructural changes associated with cerebellar atrophy in patients with essential tremor.-Feasibility of using DW-MRS in clinical settings to measure non-Gaussian diffusivities of metabolites and provide insights into secondary neuronal structures.

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Keywords