Abstract #0596

In vivo Glx measurements from GABA-edited HERMES at 3T are not consistent with those from short-TE PRESS across scanners, regions, and age groups.

Alice R Thomson^1,2, Pascal Aggensteiner³, Herbert Roeyers⁴, Terje Falck-Ytter⁵, Eva Loth¹, Jan K Buitelaar⁶, Declan Murphy¹, Tomoki Arichi^7,8, and Nicolaas A Puts^1,2

¹Department of Forensic and Neurodevelopmental Sciences, King's College London, London, United Kingdom, ²MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom, ³Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany, ⁴Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium, ⁵Development and Neurodiversity Lab, Department of Psychology, Uppsala University, Uppsala, Sweden, ⁶Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands, ⁷MRC Centre for Neurodevelopmental Disorders, King’s College London, London, United Kingdom, ⁸Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

Synopsis

Keywords: Spectroscopy, Brain, Neuro, Glutamate, metabolite, HERMES, PRESSS, edited-MRS

Motivation: The reliability of 80ms HERMES for quantification of Glx (glutamate + glutamine) has not been assessed.

Goal(s): Investigate the agreement between paired Glx measurements from GABA-edited HERMES (TE = 80ms) and conventional PRESS (TE = 35ms).

Approach: HERMES and PRESS were acquired from two voxels (anterior cingulate cortex and thalamus) across 272 participants, 4 scanners, 2 age groups and 2 diagnostic groups.

Results: We observe poor agreement between HERMES and PRESS Glx measurements, with consistent systematic and proportional differences between measurements across all scanners, age groups and diagnostic groups.

Impact: In a large sample, we show that HERMES (TE = 80ms) Glx estimates are not consistent with paired Glx measurements from short-TE PRESS, highlighting the need for consideration during MRS sequence selection, integrating data across different acquisitions, and data interpretation.

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