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Abstract #0599

Probing transient changes in intracellular-extracellular lactate distribution in the mouse brain during i.v. lactate infusion using dMRS

Sophie Malaquin1, Julien Valette1, and Celine Baligand1
1Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France

Synopsis

Keywords: Spectroscopy, Metabolism, Diffusion-weighted MRS

Motivation: Diffusion-weighted MR spectroscopy can be used to non-invasively assess lactate intracellular-extracellular compartmentation in the brain at equilibrium, but long measurement times may hamper detection of any transient changes.

Goal(s): Detecting transient changes in lactate distribution would be invaluable to study lactate dynamics.

Approach: We propose to use dMRS to non-invasively detect transient changes in lactate compartmentation induced by intravenous lactate infusion in the mouse brain.

Results: we were able to capture transient changes in lactate concentration and distribution in the mouse brain with a time resolution of 6 minutes.

Impact: We were able to non-invasively capture transient changes in intracellular-extracellular lactate distribution using dMRS, and it would be invaluable to estimate its vascular fraction and exchange kinetics between compartments to better understand lactate’s role in brain function.

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