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Abstract #0603

Novel lipid-targeted echo-planar spectroscopic imaging technique for in-vivo lipid composition measurement

Dingyi Lin1, Ke Zhou1, Yufan Zhou1, Xinyi Zhu1, Shiyang You1, Yang Cao1, Jiaqiang Zhou2, Feng Chen3, Chunli Cai4, Yi-Cheng Hsu5, and Min Wang1,2
1Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, 2Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China, 3Department of Radiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, 4Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, China, 5MR Collaboration, Siemens Healthcare Ltd, Shanghai, China

Synopsis

Keywords: Spectroscopy, Body, lipid composition; echo-planar spectroscopic imaging

Motivation: Understanding lipid metabolism requires investigating lipid composition in vivo across tissues, which necessitates rapid, high-resolution chemical-shift imaging.

Goal(s): To develop a novel, practical lipid composition imaging technique that provides full coverage of the upper abdominal volume.

Approach: We introduced a Csar-EPSI sequence with adiabatic pulses to selectively refocus lipids and effectively suppress water, enhancing scan efficiency, reducing chemical-shift displacement errors, and allowing flexible voxel selection for consistent lipid assessments.

Results: Csar-EPSI demonstrated high time efficiency, improved reliability, and precise differentiation of lipid profiles between obese and healthy control mice, providing a robust foundation for future applications in high-field human abdominal MRI.

Impact: Csar-EPSI enables rapid and precise assessment of lipid composition in vivo. Its enhanced sensitivity and reliability provide critical insights into metabolic disorders, paving the way for improved diagnostics and personalized treatments in high-field human abdominal MRI applications.

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