Meeting Banner
Abstract #0605

Metabolite T1 and T2 relaxation times in the macaque brain at 11.7T with local B1+ shimming

Alfredo Liubomir Lopez Kolkovsky1, Marion Gay1, Maxime Roustan1, Thomas Lilin Froment1, Aurélien Massire2, Alexis Amadon1, Franck Mauconduit1, and Fawzi Boumezbeur1
1NeuroSpin, CEA, Gif-sur-Yvette, France, 2Siemens Healthineers, Courbevoie, France

Synopsis

Keywords: Spectroscopy, Metabolism

Motivation: Knowledge of metabolite T1 and T2 relaxation times is needed for optimal pulse sequence parameterization and to account for partial T1 saturation and T2 decay during metabolite quantification.

Goal(s): To measure metabolite relaxation times in the macaque brain at 11.7T with a 6Tx/6Rx surface coil.

Approach: Multi-echo and inversion-recovery acquisitions with STEAM combined with a B1+-shimming configuration optimized for the MRS voxel.

Results: Performing voxel-specific B1+-shimming reduced the required RF power by 40% (±11%) . Measured T1 values were in agreement with the literature while T2 values were lower than those measured with LASER in the rat brain at 11.7T.

Impact: Increased accuracy for metabolite concentration estimation and optimal acquisition parameters to maximize temporal SNR at 11.7T. Parallel transmission elicited a large reduction in the required RF power for a 2.25 mL cortical voxel using a dedicated 6Tx/6Rx surface coil.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords