Keywords: Spectroscopy, Metabolism
Motivation: Knowledge of metabolite T1 and T2 relaxation times is needed for optimal pulse sequence parameterization and to account for partial T1 saturation and T2 decay during metabolite quantification.
Goal(s): To measure metabolite relaxation times in the macaque brain at 11.7T with a 6Tx/6Rx surface coil.
Approach: Multi-echo and inversion-recovery acquisitions with STEAM combined with a B1+-shimming configuration optimized for the MRS voxel.
Results: Performing voxel-specific B1+-shimming reduced the required RF power by 40% (±11%) . Measured T1 values were in agreement with the literature while T2 values were lower than those measured with LASER in the rat brain at 11.7T.
Impact: Increased accuracy for metabolite concentration estimation and optimal acquisition parameters to maximize temporal SNR at 11.7T. Parallel transmission elicited a large reduction in the required RF power for a 2.25 mL cortical voxel using a dedicated 6Tx/6Rx surface coil.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords