Abstract #0614

Ultrahigh-Resolution Mapping of Brain Metabolic Structures at Ultrahigh Field

Rong Guo^1,2, Yudu Li^2,3,4, Yibo Zhao², Wen Jin^2,5, Yuhui Chai², Yao Li⁶, Brad Sutton^2,3,4, and Zhi-Pei Liang^2,4,5

¹Siemens Healthineers, St Louis, MO, United States, ²Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁵Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁶School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

Synopsis

Keywords: Spectroscopy, Spectroscopy, ultrahigh field

Motivation: Metabolic imaging using MRSI has long been limited to low resolution, restricting its ability to capture fine metabolic structures.

Goal(s): To achieve high-resolution mapping of brain metabolic structures by leveraging the power of ultrahigh field MR.

Approach: An FID-EPSI based sequence was used with extended readouts for data acquisition, achieving an isotropic nominal resolution of 1.8 mm. In data processing, model-based methods were applied for ghost correction, denoising, and de-aliasing to produce high-quality ultrahigh-resolution MRSI results.

Results: The proposed method enabled ultrahigh-resolution metabolic imaging at 7T, which allowed for detailed visualization of metabolite distributions in the brain.

Impact: This work demonstrates the feasibility of ultrahigh-resolution mapping of brain metabolic structures using MRSI. The proposed method offers a new potential for exploring brain metabolism with unprecedented details.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.