Abstract #0644

Markerless prospective motion correction assisted functional MRS during motor activation using PRESS sequence at 3T

Yiling Liu¹, Yu Wei¹, Yanxing Yang², Xinyue Zhang², Jiaqi Zhao², Philip Kenneth Lee¹, Assaf Tal³, Hao Chen¹, and Zhiyong Zhang¹

¹School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ²United Imaging Healthcare, Shanghai, China, ³Department of Bio-Medical Engineering, Tel Aviv University, Tel Aviv, Israel

Synopsis

Keywords: Data Acquisition, Spectroscopy, functional MRS (fMRS), motor task, markerless prospective motion correction (PMC)

Motivation: Conducting functional magnetic resonance spectroscopy (fMRS) studies in clinical conditions is challenging due to low SNR and small neurochemical changes.

Goal(s): Investigate the feasibility of PRESS fMRS studies at 3T assisted by a prospective motion correction (PMC) system.

Approach: A markerless PMC system was applied to an fMRS study during motor activation with a task paradigm consisting of three blocks REST-TASK-REST. The same motor task was repeated twice, once with PMC ON and once with PMC OFF.

Results: A statistically significant increase in Glx of 5.75% was observed with PMC ON. No metabolite changes were observed with PMC OFF.

Impact: With the assistance of a markerless prospective motion correction system, fMRS at 3T with a clinically feasible protocol is capable of detecting small changes of a few percent in Glx concentrations during functional activation.

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