Abstract #0657

Simultaneous zero echo time fMRI of rat brain and spinal cord

Hanne Laakso¹, Lin Wu², Sara Ponticorvo², Raimo A. Salo¹, Jaakko Paasonen¹, Ekaterina Paasonen¹, Mikko Kettunen¹, Russell L. Lagore², Lance DeLabarre², Ethan Polcyn², Gregor Adriany², Javier Istúriz³, Dee M. Koski², Djaudat Idiyatullin², Olli Gröhn¹, Silvia Mangia², and Shalom Michaeli²

¹A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ²Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ³Neos Biotec, Pamplona, Spain

Synopsis

Keywords: fMRI Acquisition, fMRI (task based), zero echo time, dual-FOV, preclinical, spinal cord

Motivation: Currently fMRI focuses on either brain or spinal cord but rarely both. This is due to the demand of homogenous magnetic field over a large FOV. A comprehensive evaluation of central nervous system from distant sites would be crucial in many disorders that encompass both the brain and the spinal cord.

Goal(s): To robustly detect fMRI responses simultaneously in rat brain and lumbar spinal cord.

Approach: We utilized zero echo time MB-SWIFT fMRI sequence with dual-FOV approach.

Results: We detected robust activations during hind limb stimulation in relevant areas of brain and spinal cord at individual and group level.

Impact: The dual-FOV zero echo time sequence enables more comprehensive evaluation of central nervous system function and reorganization in different diseases or disorders such as pain and spinal cord injury.

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