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Abstract #0661

fMRI in Fully Myelinated White Matter: Evidence of Absent Signal

David Esteban Suarez-Baquero1, Davide Boido2, Serge Charpak1, and Luisa Ciobanu2
1Sorbonne Université, Institut de la Vision, INSERM, Paris, France, 2NeuroSpin, Paris-Saclay University, CEA, Saclay, France

Synopsis

Keywords: fMRI Acquisition, fMRI Acquisition

Motivation: Recent studies report evoked white matter BOLD signals in the human brain. However, their origin is not clearly established.

Goal(s): Determine whether both myelinated and unmyelinated axons are responsible for BOLD-fMRI responses measured in white matter.

Approach: Investigate whether visual stimulation induces vascular responses in the rodent optic nerve, which contains only myelinated axons, using a multiscale imaging approach, combining BOLD-fMRI and two-photon microscopy.

Results: Visual stimulation does not induce changes in blood flow or oxygenation in the rodent optic nerve, indicating that fully myelinated structures do not contribute to white matter BOLD-fMRI signals.

Impact: This study contributes to our understanding of brain imaging techniques that rely on blood flow, including BOLD-fMRI, serving as a prerequisite for interpreting such imaging in both healthy and pathological conditions.

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