Abstract #0664

Distortion-Free Diffusion-Weighted Imaging of the Prostate Using TGSE-Based Golden-Angle PROPELLER Acquisition and Deep Learning Denoising

Jingjia Chen^1,2, Kun Zhou³, Mary T Bruno^1,2, Hersh Chandarana^1,2, Daniel K Sodickson^1,2, Qiuting Wen⁴, and Li Feng^1,2

¹Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ³Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, ⁴Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

Synopsis

Keywords: Diffusion Acquisition, Acquisition Methods, Prostate, Distortion-free, Denoising

Motivation: Clinical single shot EPI-DWI suffers from low resolution and geometric distortion.

Goal(s): To achieve distortion-free, high-resolution prostate DWI within the same or shorter scan time as the clinical routine.

Approach: We developed a novel Turbo Gradient Spin Echo (TGSE) PROPELLER DWI acquisition scheme for prostate imaging, incorporating a self-supervised model for denoising. Blades corresponding to the same b-values are combined to produce b50 and b1000 images for ADC fitting.

Results: DWI images generated with TGSE-PROPELLER-DWI are distortion-free, even in cases with metal implants or strong air-tissue induced B0 inhomogeneity. Higher-than-clinical resolution is achievable with the same scan time.

Impact: TGSE-PROPELLER-DWI with a novel acquisition scheme provides distortion-free, high-resolution prostate DWI within the same scan time as the clinical protocol, with potential for further scan time reduction.

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