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Abstract #0672

Simultaneous Multi-Slice DKI in Hepatocellular Carcinoma: Correlation with Early Recurrence

Yingyi Wu1, Zheng Ye1, and Bin Song1,2,3
1Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, 2Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China, 3Department of Radiology, Sanya People’s Hospital, Sanya, China

Synopsis

Keywords: DWI/DTI/DKI, Acquisition Methods, Hepatocellular carcinoma, Simultaneous multislice imaging, Early recurrence, Prognosis.

Motivation: While DKI effectively predicts HCC malignancy, its clinical use is limited by lengthy acquisition times (4–5 min). Simultaneous Multi-Slice (SMS) technology shortens DKI scan times in liver imaging, yet its potential for predicting HCC recurrence remains unexplored.

Goal(s): To evaluate SMS-DKI for predicting early recurrence in HCC and develop a predictive model.

Approach: Sixty-seven HCC patients underwent MRI with SMS-accelerated DKI (140 sec) and routine sequences. Diffusion parameters and radiological features were analyzed by three radiologists.

Results: SMS-MK, non-smooth margins, absence of capsule, and larger tumor volume were independent predictors, achieving an AUC of 0.94 in predictive model.

Impact: The improved acquisition speed using SMS may facilitate the integration of DKI into routine liver imaging workflows. This preliminary evidence for SMS-DKI in predicting early recurrence in HCC also encourages further exploration of its applicability in other tumor types.

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Keywords