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Abstract #0676

Single-shot spiral MR-ARFI with Model-Based Displacement Map Reconstruction in Non-Human Primates

Saikat Sengupta1, M. Anthony Phipps1, Li Min Chen1, Charles Caskey1,2, and William A Grissom3
1Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, United States, 2Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 3Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Synopsis

Keywords: MR-Guided Focused Ultrasound, Focused Ultrasound, ARFI

Motivation: MR-ARFI visualizes the ultrasound focus for targeting ultrasound neuromodulation, but has poor sensitivity when used within FDA mechanical index (MI) limits.

Goal(s): Implement a recent single-shot spiral MR-ARFI method, evaluate it in non-human primates, and make it robust to dynamic phase errors.

Approach: A single-shot spiral interleaved MR-ARFI pulse sequence was implemented to acquire data in NHP brain. A model-based reconstruction was developed.

Results: The spiral sequence detected displacement at an MI of 1.2, well below the FDA limit of 1.9, which 3D EPI could not detect. The model-based reconstruction suppressed background phase errors and maximized precision.

Impact: Used within current FDA limits, MR-ARFI has poor sensitivity for visualizing the ultrasound focus to target neuromodulation. We show that a recent spiral MR-ARFI method enables focus visualization in vivo within limits, and we maximize its sensitivity with model-based reconstruction.

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